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Inventi Impact: Genetics

Articles

  • Inventi:hgt/26606/18
    Rs4612666 Polymorphism of the NLRP3 Gene Is Associated with the Occurrence of Large Artery Atherosclerotic Ischemic Strokes and Microembolic Signals
    01-Jan-1970 Research 2018 : October - December
    Lufeng Cheng, Ruihua Yin, Shaonan Yang, Xudong Pan, Aijun Ma

    Purpose. Large artery atherosclerosis (LAA) ischemic stroke (IS) is the most common IS subtype, and microemboli are clinically\nimportant for indicating an increased risk of IS. Nucleotide-binding domain-like receptor protein 3 (NLRP3) plays a crucial role\nin the pathogenesis of atherosclerosis. The aim of this study is to investigate the relationship between NLRP3 gene polymorphisms\nand susceptibility for LAA IS and microembolic signals (MES) in the Chinese Han population. Methods. We studied 293 patients\ndiagnosed with LAAIS and 265 controls.TranscranialDoppler (TCD) was used tomonitor theMESin all of the patients.Depending\non the presence or absence of MES, the patients were divided into MES-positive and MES-negative subgroups. PCR-RFLP or direct\nsequencingwere used to analyze threeNLRP3 gene polymorphisms. Results. Seventy-six patients presentedwith MES and the MESpositive\nrate was 25.94%. Logistic regression analysis showed that the TT genotype frequency for the rs4612666 gene polymorphism\nwas higher in study patients than in the controls (adjusted

    How to Cite this Article
    Lufeng Cheng, Ruihua Yin, Shaonan Yang, Xudong Pan, and Aijun Ma, â??Rs4612666 Polymorphism of the NLRP3\nGene Is Associated with the Occurrence of Large Artery Atherosclerotic Ischemic Strokes and Microembolic Signals,â? BioMed Research\nInternational, vol. 2018, Article ID 6345805, 9 pages, 2018. https://doi.org/10.1155/2018/6345805, https://creativecommons.org/\nlicenses/by/4.0/.
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